产品名称

CBR 5884

产品货号

Axon 2585 CAS [681159-27-3] MF C14H12N2O4S2MW 336.39 Purity: 99% Soluble in DMSO Description Noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH; IC50 value 33 µM) with selective toxicity towards cancer cell lines with high serine biosynthetic activity. CBR-5884 shows no inhibitory effect on two other NAD+-dependent dehydrogenases, lactate dehydrogenase (LDH) and MDH1A. A useful tool to study the biology of de novo serine synthesis enabling preclinical evaluation of PHGDH as a target in cancer. KEYWORDS: CBR 5884 | supplier | PHGDH inhibitor | CBR5884 | CAS [681159-27-3] | 3-phosphoglycerate | PHGDH | dehydrogenase | breast | cancer | serine biosynthesis | NAD+ dependent

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CBR 5884

Based on 6 reference(s) in Google Scholar 9 10 6

Axon 2585

CAS [681159-27-3]

MF C14H12N2O4S2
MW 336.39

Purity: 99%
Soluble in DMSO

CBR 5884

Description

Noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH; IC50 value 33 µM) with selective toxicity towards cancer cell lines with high serine biosynthetic activity. CBR-5884 shows no inhibitory effect on two other NAD+-dependent dehydrogenases, lactate dehydrogenase (LDH) and MDH1A. A useful tool to study the biology of de novo serine synthesis enabling preclinical evaluation of PHGDH as a target in cancer.

E Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83.

E Mullarky et al. A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase. Mol Cell Oncol. 2016 Mar 30;3(4):e1164280.

Noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH)

Chemical name

ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate

Parent CAS No.

[681159-27-3]

产品资料