| 产品名称 | PBTZ169 |
| 产品货号 | Axon 2626 CAS [1377239-83-2] MF C20H23F3N4O3SMW 456.48 Purity: 100% Soluble in DMSO and Ethanol Description Potent irreversible DprE1 inhibitor (MIC value <0.19 ng/mL and <0.004 µM against M. tuberculosis H37Ra) with improved stability against nitroreductase metabolism, and good efficacy at lower concentrations in the murine model of chronic tuberculosis (TB); an attractive drug candidate to treat TB in humans. The combination of PBTZ169, BDQ and pyrazinamide was found to be more efficacious than the standard three drug treatment in a murine model of chronic disease. KEYWORDS: PBTZ169 | supplier | DprE1 inhibitor | PBTZ-169 | PBTZ 169 | CAS [1377239-83-2] | DPR | DprE | tuberculosis | TB | mycobacterium | flavo-enzyme | cell wall | biosynthesis | benzothiazinone | epimerase | Decaprenylphosphoryl-beta-D-ribofuranose |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
PBTZ169Axon 2626 CAS [1377239-83-2] MF C20H23F3N4O3S
DescriptionPotent irreversible DprE1 inhibitor (MIC value <0.19 ng/mL and <0.004 µM against M. tuberculosis H37Ra) with improved stability against nitroreductase metabolism, and good efficacy at lower concentrations in the murine model of chronic tuberculosis (TB); an attractive drug candidate to treat TB in humans. The combination of PBTZ169, BDQ and pyrazinamide was found to be more efficacious than the standard three drug treatment in a murine model of chronic disease. KEYWORDS: PBTZ169 | supplier | DprE1 inhibitor | PBTZ-169 | PBTZ 169 | CAS [1377239-83-2] | DPR | DprE | tuberculosis | TB | mycobacterium | flavo-enzyme | cell wall | biosynthesis | benzothiazinone | epimerase | Decaprenylphosphoryl-beta-D-ribofuranose
Potent irreversible DprE1 inhibitor; tuberculosis therapeutic
Chemical name2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one Parent CAS No.[1377239-83-2] |
| 产品资料 |
