产品名称

EN460 - ERO1 Inhibitor II

产品货号

Axon 2737 CAS [496807-64-8] MF C22H12ClF3N2O4MW 460.79 Purity: 99% Soluble in DMSO Description EN460, an inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50 value of 1.9 μM). Despite rapid and promiscuous reactivity with thiolates, EN460 exhibits selectivity for ERO1. KEYWORDS: EN460 | supplier | ERO1 inhibitor | ERO1 Inhibitor II | EN 460 | EN-460 | CAS [496807-64-8] | Protein Disulfide Isomerase (PDI) | ERO1 | Inhibitor | Enzymes | Endoplasmic Reticulum Oxidation

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

EN460 - ERO1 Inhibitor II

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2737

CAS [496807-64-8]

MF C22H12ClF3N2O4
MW 460.79

Purity: 99%
Soluble in DMSO

EN460

Description

EN460, an inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50 value of 1.9 μM). Despite rapid and promiscuous reactivity with thiolates, EN460 exhibits selectivity for ERO1.

JD Blais et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003.

Epigenetics Miscellaneous ERO1

Inhibitor of endoplasmic reticulum oxidation 1 (ERO1)

Chemical name

(Z)-2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Parent CAS No.

[496807-64-8]

产品资料