产品名称

IACS-010759 - IACS-10759

产品货号

Axon 2909 CAS [1570496-34-2] MF C25H25F3N6O4SMW 562.56 Purity: 99% Soluble in DMSO Description IACS-010759 is an orally bioavailable, potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). IACS-010759 was active in mouse, rat and cynomolgus monkey with IC50 values of 5.6 nM, 12.2 nM and 8.7 nM, respectively. Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis. KEYWORDS: IACS-010759 | supplier | OxPhos inhibitor | IACS-10759 | IACS 010759 | IACS010759 | IACS 10759 | IACS10759 | CAS [1570496-34-2] | NADH | NADH dehydrogenase | Inhibitor | Enzymes | OxPhos | Complex I | Brain cancer | AML

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

IACS-010759 - IACS-10759

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2909

CAS [1570496-34-2]

MF C25H25F3N6O4S
MW 562.56

Purity: 99%
Soluble in DMSO

IACS-010759

Description

IACS-010759 is an orally bioavailable, potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). IACS-010759 was active in mouse, rat and cynomolgus monkey with IC50 values of 5.6 nM, 12.2 nM and 8.7 nM, respectively. Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.