产品名称

TH 5487

产品货号

Axon 2934 CAS [2304947-71-3] MF C19H18BrIN4O2MW 541.18 Purity: 98% Soluble in DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

TH 5487

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2934

CAS [2304947-71-3]

MF C19H18BrIN4O2
MW 541.18

Purity: 98%
Soluble in DMSO

Recently added

TH 5487

Description

TH 5487 is a potent and selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with an IC50 of 342 nM. TH 5487 inhibited DNA repair and modified OGG1 chromatin dynamics, which resulted in the inhibition of proinflammatory pathway genes. Furthermore, TH 5487 was well tolerated by mice and suppressed lipopolysaccharide- and tumor necrosis factor–α–mediated neutrophilic inflammation in the lungs.

T Visnes et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839.

Potent and selective active-site OGG1 inhibitor

Chemical name

4-(4-Bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide

Parent CAS No.

[2304947-71-3]

产品资料