产品名称

WNK Inhibitor 11

产品货号

Axon 2896 CAS [2123489-30-3] MF C21H21Cl2N5OSMW 462.40 Purity: 98% Soluble in DMSO Description Selective allosteric WNK1 inhibitor (IC50 value of 0.004 µM) with nearly 1000-fold selectivity for WNK1 vs WNK4 and 57-fold selectivity for WNK1 vs WNK2. Keywords: WNK Inhibitor 11 | supplier | WNK1 inhibitor | CAS [2123489-30-3] | Cation-Cl− cotransporters (CCCs) | WNK | Inhibitor | Enzymes | Hypertension

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

WNK Inhibitor 11

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2896

CAS [2123489-30-3]

MF C21H21Cl2N5OS
MW 462.40

Purity: 98%
Soluble in DMSO

WNK Inhibitor 11

Description

Selective allosteric WNK1 inhibitor (IC50 value of 0.004 µM) with nearly 1000-fold selectivity for WNK1 vs WNK4 and 57-fold selectivity for WNK1 vs WNK2.

K Yamada et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107.

Cardiovascular EC 2.7.11.1 WNK

Selective allosteric inhibitor of WNK1

Chemical name

(5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone

Parent CAS No.

[2123489-30-3]

产品资料