产品名称

BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride

产品货号

Axon 2373 CAS [222638-67-7] MF C5H12BNO4S.HClMW 229.49 Purity: 99% Soluble in water and DMSO Description Slow-binding pH-dependent inhibitior of human Arginase I and II (Kd value 270 nM and 220 nM for Arginase I and II, respectively. Ki values 310 nM and 30 nM at pH 7.5 and pH 9.5, respectively for Arginase II). Valuable reagent to probe the physiological relationship between arginase and nitric oxide (NO) synthase in regulating the NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. BEC Does not inhibit NO synthase, and effectively prevented ACh tolerance in aortic and mesenteric artery preparations. KEYWORDS: BEC hydrochloride | supplier | Arginase inhibitor | S-(2-Boronoethyl)-L-cysteine hydrochloride | CAS [222638-67-7] | [63107-40-4] | Axon Medchem | Axon 2373 | Arginine | Arginase | Arginase II | Arginase I | Arginemia | NO | penile | sexual | dysfunction | ureagenesis | Arginine | urea cycle | Ornithine cycle | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2373

CAS [222638-67-7]

MF C5H12BNO4S.HCl
MW 229.49

Purity: 99%
Soluble in water and DMSO

BEC hydrochloride

Description

Slow-binding pH-dependent inhibitior of human Arginase I and II (Kd value 270 nM and 220 nM for Arginase I and II, respectively. Ki values 310 nM and 30 nM at pH 7.5 and pH 9.5, respectively for Arginase II). Valuable reagent to probe the physiological relationship between arginase and nitric oxide (NO) synthase in regulating the NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.
BEC Does not inhibit NO synthase, and effectively prevented ACh tolerance in aortic and mesenteric artery preparations.

KEYWORDS: BEC hydrochloride | supplier | Arginase inhibitor | S-(2-Boronoethyl)-L-cysteine hydrochloride | CAS [222638-67-7] | [63107-40-4] | Axon Medchem | Axon 2373 | Arginine | Arginase | Arginase II | Arginase I | Arginemia | NO | penile | sexual | dysfunction | ureagenesis | Arginine | urea cycle | Ornithine cycle | Inhibitor | Enzymes

N.N. Huynh et al. The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br. J. Pharmacol. 2009, 156, 84-93.

S.M. Khong et al. Arginase II inhibition prevents nitrate tolerance. Br J Pharmacol. 2012, 166, 2015-2023.

D.M. Colleluori et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001, 40, 9356-9362.

N.N. Kim et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001, 40, 2678-2688.

L. Di Costanzo et al. Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response. Proc. Natl. Acad. Sci. USA. 2005, 102, 13058-13063.

Cardiovascular Cell Signaling & Oncology Immunology EC 3.5.3.1 Arginase

Slow-binding pH-dependent inhibitior of Ariginase I and II

Chemical name

(R)-2-Amino-3-(2-boronoethylthio)propanoic acid hydrochloride

Parent CAS No.

[63107-40-4]

产品资料