| 产品名称 | Cambinol - NSC 112546 |
| 产品货号 | Axon 2803 CAS [14513-15-6] MF C21H16N2O2SMW 360.43 Purity: 99% Soluble in DMSO Description Cambinol inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2 (IC50 values of 56 and 59 μM, respectively). Consistent with the role of SIRT1 in promoting cell survival during stress, inhibition of SIRT1 activity with cambinol during genotoxic stress leads to hyperacetylation of key stress response proteins and promotes cell cycle arrest. Cambinol exerts antitumor activity in vitro and in mouse xenograft studies. Moreover, cambinol is an uncompetitive nSMase2 inhibitor (Ki value of 7 μM). KEYWORDS: Cambinol | supplier | SIRT inhibitor | NSC 112546 | NSC112546 | NSC-112546 | CAS [14513-15-6] | Histone | SIRT | Inhibitor | Enzymes | nSMase2 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
Cambinol - NSC 112546Axon 2803 CAS [14513-15-6] MF C21H16N2O2S
DescriptionCambinol inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2 (IC50 values of 56 and 59 μM, respectively). Consistent with the role of SIRT1 in promoting cell survival during stress, inhibition of SIRT1 activity with cambinol during genotoxic stress leads to hyperacetylation of key stress response proteins and promotes cell cycle arrest. Cambinol exerts antitumor activity in vitro and in mouse xenograft studies. Moreover, cambinol is an uncompetitive nSMase2 inhibitor (Ki value of 7 μM). KEYWORDS: Cambinol | supplier | SIRT inhibitor | NSC 112546 | NSC112546 | NSC-112546 | CAS [14513-15-6] | Histone | SIRT | Inhibitor | Enzymes | nSMase2
Inhibitor of SIRT1 and SIRT2
Chemical name5-((2-Hydroxynaphthalen-1-yl)methyl)-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one Parent CAS No.[14513-15-6] |
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