产品名称

GAT107

产品货号

Axon 2621 CAS [1476807-74-5] MF C18H17BrN2O2SMW 405.31 Purity: 99% Optical purity: >99% Soluble in DMSO Description GAT107, the bioactive enantiomer of 4BP-TQS (Axon 2694), is an allosteric agonist (EC50 value 28 μM) and positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors. GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain. KEYWORDS: GAT107 | supplier | α7 nAChR agonist and PAM | GAT-107 | GAT 107 | CAS [1476807-74-5] | Acetylcholine | nAChR | Allosteric agonist | Ion Channels

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GAT107

Based on 18 reference(s) in Google Scholar 10 10 18

Axon 2621

CAS [1476807-74-5]

MF C18H17BrN2O2S
MW 405.31

Purity: 99%
Optical purity: >99%
Soluble in DMSO

GAT107

Description

GAT107, the bioactive enantiomer of 4BP-TQS (Axon 2694), is an allosteric agonist (EC50 value 28 μM) and positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors. GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.

GA Thakur et al. Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS).... J Med Chem. 2013 Nov 14;56(21):8943-7.

D Bagdas. The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception inmouse models of inflammatory and neuropathic pain. Br J Pharmacol. 2016 Aug;173(16):2506-20.

allosteric agonist and PAM of α7 nAChR

Chemical name

(3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Parent CAS No.

[1476807-74-5]

产品资料