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产品名称 A 804598
产品货号 Axon 2182 CAS [1125758-85-1] MF C19H17N5MW 315.37 Purity: 99% Optical purity: >99% e.e. Soluble in DMSO Description Potent and selective P2X7 antagonist (IC50 values 10 nM, 9 nM, and 11 nM for rat, mouse, and human receptors respectively). A 804598 potently blocked agonist stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.In another study, A 804598 was found to produce a concentration-dependent inhibition of BZ-ATP-stimulated calcium influx (IC50 value 28.71 nM) in cells expressing the rat recombinant P2X7 receptor; a useful tool for autoradiographic localization of P2X7 receptors in the rat brain and spinal cord. References Certificates Categories Extra info D.L. Donnelly-Roberts et al. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharm. 2009, 56, 223–229. S.L. Able et al. Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br. J. Pharmacol. 2011, 162, 405–414.  Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology CNS Pain & Inflammation P2X7 Unclassified Potent and selective P2X7 antagonist Chemical name (S)-2-cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine Parent CAS No. [1125758-85-1] Order Size Unit Price Stock 10 mg €125.00 In Stock
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A 804598

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2182

CAS [1125758-85-1]

MF C19H17N5
MW 315.37

  • Purity: 99%
  • Optical purity: >99% e.e.
  • Soluble in DMSO

A 804598

Description

Potent and selective P2X7 antagonist (IC50 values 10 nM, 9 nM, and 11 nM for rat, mouse, and human receptors respectively). A 804598 potently blocked agonist stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors.In another study, A 804598 was found to produce a concentration-dependent inhibition of BZ-ATP-stimulated calcium influx (IC50 value 28.71 nM) in cells expressing the rat recombinant P2X7 receptor; a useful tool for autoradiographic localization of P2X7 receptors in the rat brain and spinal cord.
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