产品名称

ZQ-16

产品货号

Axon 2616 CAS [376616-73-8] MF C10H16N2O2SMW 228.31 Purity: 99% Soluble in DMSO and Ethanol Description Potent and selective small-molecule GPR84 agonist (EC50 value 0.139 µM in a calcium mobilization assay). ZQ-16 induced phosphorylation of ERK1/2, and a dose-dependent reduction of forskolin-stimulated cAMP accumulation in HEK293 cells expressing GPR84. KEYWORDS: ZQ-16 | supplier | GPR84 agonist | ZQ16 | CAS [376616-73-8] | FFA | GPR84 | GPCR | free fatty acids | ERK1 | ERK3 | inflammation | immunology | cAMP

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ZQ-16

Based on 2 publications in PubMed 8 10 2

Axon 2616

CAS [376616-73-8]

MF C10H16N2O2S
MW 228.31

Purity: 99%
Soluble in DMSO and Ethanol

ZQ-16

Description

Potent and selective small-molecule GPR84 agonist (EC50 value 0.139 µM in a calcium mobilization assay). ZQ-16 induced phosphorylation of ERK1/2, and a dose-dependent reduction of forskolin-stimulated cAMP accumulation in HEK293 cells expressing GPR84.

KEYWORDS: ZQ-16 | supplier | GPR84 agonist | ZQ16 | CAS [376616-73-8] | FFA | GPR84 | GPCR | free fatty acids | ERK1 | ERK3 | inflammation | immunology | cAMP

Q Zhang et al. Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84. J Pharmacol Exp Ther. 2016 May;357(2):337-44.

Y Liu et al. Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83.

Potent and selective GPR84 agonist that induces phosphorylation of ERK1/2

Chemical name

2-(hexylthio)pyrimidine-4,6-diol

Parent CAS No.

[376616-73-8]

产品资料