产品名称

AMG 837 calcium salt

产品货号

Axon 2405 CAS [1291087-14-3] MF C26H20F3O3.½CaMW 457.47 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Orally bioavailable partial agonist of the GPR40 (EC50 value 13.5 nM for AMG 837 stimulated Ca2+ flux in CHO cells expressing human GPR40) with a superior pharmacokinetic profile. AMG837 stimulated robust glucose-dependent insulin secretion (EC50 value 142±20 nM) in isolated rodent islets, and lowered post-prandial glucose in normal rats. AMG-837 exhibits a potential utility for the treatment of type 2 diabetes. References Certificates Categories Extra info D.C. Lin et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011;6(11):e27270. J.B. Houze et al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1267-70. J. Luo et al. A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents. PLoS One. 2012;7(10):e46300. Y.J. Choi et al. G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes. Arch Pharm Res. 2014 Apr;37(4):435-9. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Diabetes & Metabolism GPR40 A11 Orally bioavailable partial agonist of GPR40 (FFA1) Chemical name (S)-3-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)hex-4-ynoic acid calcium salt Parent CAS No. [865231-46-5] Order Size Unit Price Stock 5 mg €110.00 In Stock

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现货询价，电话：010-67529703

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axonmedchem

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AMG 837 calcium salt

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2405

CAS [1291087-14-3]

MF C26H20F3O3.½Ca
MW 457.47

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

AMG 837 calcium salt

Description

Orally bioavailable partial agonist of the GPR40 (EC50 value 13.5 nM for AMG 837 stimulated Ca2+ flux in CHO cells expressing human GPR40) with a superior pharmacokinetic profile. AMG837 stimulated robust glucose-dependent insulin secretion (EC50 value 142±20 nM) in isolated rodent islets, and lowered post-prandial glucose in normal rats. AMG-837 exhibits a potential utility for the treatment of type 2 diabetes.