SSR 149415 - Nelivaptan

Based on 234 reference(s) in Google Scholar 10 10 234

Axon 1114

CAS [439687-69-1]

MF C30H32ClN3O8S
MW 630.11

Purity: 99%
Optical purity: >98% ee
Soluble in DMSO

SSR 149415

Description

Selective and orally active non-peptide antagonist of vasopressin V1b receptor (Ki values 91 nM and 1.5 nM for V1a and V1b in human CHO cells, respectively); a potential drug for treatment of anxiety and depression.

G Griebel et al. Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders. PNAS U.S.A. 2002, 99(9), 6370-6375.

GC Serradeil-Le et al. An overview of SSR149415, a selective nonpeptide vasopressin V(1b) receptor antagonist for the treatment of stress-related disorders. CNS drug reviews 2005, 11(1), 53–68.

List of publications utilizing SSR 149415 - Nelivaptan (Axon 1114) purchased from Axon Medchem

Cardiovascular CNS A6 Vasopressin (V)

Vasopressin (V1B) antagonist

Chemical name

(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide

Parent CAS No.

[439687-69-1]

产品资料