产品名称

Calhex 231 hydrochloride

产品货号

Axon 1818 CAS [N.A.] MF C25H27ClN2O.HClMW 443.41 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Negative allosteric modulator (NAM) of the extracellular Calcium-sensing receptor (CaSR or CaR); inhibit Ca2+-induced accumulation of [3H]inositol phosphates in HEK293 cells (IC50: 0.39 microm) References Certificates Categories Extra info C Petrel et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. J. Biol. Chem. 2003, 278(49), 49487-49494. A Kessler et al. N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand (...). J. Med. Chem. 2006, 49(17), 5119-5128. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS CaSR C1 NAM of the extracellular CaSR Chemical name 4-chloro-N-((1S,2S)-2-((R)-1-(naphthalen-1-yl)ethylamino)cyclohexyl)benzamide hydrochloride Parent CAS No. [652973-93-8] Order Size Unit Price Stock 5 mg €99.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Calhex 231 hydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1818

CAS [N.A.]

MF C25H27ClN2O.HCl
MW 443.41

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Calhex 231 hydrochloride

Description

Negative allosteric modulator (NAM) of the extracellular Calcium-sensing receptor (CaSR or CaR); inhibit Ca2+-induced accumulation of [3H]inositol phosphates in HEK293 cells (IC50: 0.39 microm)

C Petrel et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. J. Biol. Chem. 2003, 278(49), 49487-49494.

A Kessler et al. N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand (...). J. Med. Chem. 2006, 49(17), 5119-5128.

NAM of the extracellular CaSR

Chemical name

4-chloro-N-((1S,2S)-2-((R)-1-(naphthalen-1-yl)ethylamino)cyclohexyl)benzamide hydrochloride

Parent CAS No.

[652973-93-8]

产品资料