产品名称

C-DIM8 - DIM-C-pPhOH

产品货号

Axon 2827 CAS [151358-47-3] MF C23H18N2OMW 338.40 Purity: 98% Soluble in DMSO Description C-DIM8 is a Nur77 (NR4A1) antagonist. Treatment of pancreatic and colon cancer cells with C-DIM8 mimics the effects of NR4A1 knockdown and decreases β1-integrin expression, β1-integrin regulated genes and responses including migration and adhesion. KEYWORDS: C-DIM8 | supplier | Nur77 antagonist | DIM-C-pPhOH | CDIM8 | CAS [151358-47-3] | Intracellular Transcription Factors | Nurr | Antagonist | Receptors | TRAIL

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

C-DIM8 - DIM-C-pPhOH

Based on 21 reference(s) in Google Scholar 8 10 21

Axon 2827

CAS [151358-47-3]

MF C23H18N2O
MW 338.40

Purity: 98%
Soluble in DMSO

C-DIM8

Description

C-DIM8 is a Nur77 (NR4A1) antagonist. Treatment of pancreatic and colon cancer cells with C-DIM8 mimics the effects of NR4A1 knockdown and decreases β1-integrin expression, β1-integrin regulated genes and responses including migration and adhesion.

S Chintharlapalli et al. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem. 2005 Jul 1;280(26):24903-14.

E Hedrick et al. The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. Mol Carcinog. 2017 Sep;56(9):2066-2075.

Nur77 antagonist

Chemical name

4-(Di(1H-indol-3-yl)methyl)phenol

Parent CAS No.

[151358-47-3]

产品资料