产品名称

C-DIM5 - DIM-C-pPhOCH3

产品货号

Axon 2828 CAS [33985-68-1] MF C24H20N2OMW 352.43 Purity: 99% Soluble in DMSO Description C-DIM5 is a Nur77 agonist. Activation of the orphan nuclear receptor Nur77 by C-DIM5 is associated with decreased cancer cell survival, induction of apoptosis, induced expression of the apoptosis gene/protein TRAIL, and inhibited tumor growth in vivo. C-DIM5 induces G0-G1–phase to S-phase arrest in Panc1 cells, and this is accompanied by Nur77-dependent induction of the cyclin-dependent kinase inhibitor p21. KEYWORDS: C-DIM5 | supplier | Nur77 agonist | DIM-C-pPhOCH3 | CDIM5 | CAS [33985-68-1] | Intracellular Transcription Factors | Nurr | Agonist | Receptors | TRAIL

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

C-DIM5 - DIM-C-pPhOCH3

Based on 25 reference(s) in Google Scholar 8 10 25

Axon 2828

CAS [33985-68-1]

MF C24H20N2O
MW 352.43

Purity: 99%
Soluble in DMSO

C-DIM5

Description

C-DIM5 is a Nur77 agonist. Activation of the orphan nuclear receptor Nur77 by C-DIM5 is associated with decreased cancer cell survival, induction of apoptosis, induced expression of the apoptosis gene/protein TRAIL, and inhibited tumor growth in vivo. C-DIM5 induces G0-G1–phase to S-phase arrest in Panc1 cells, and this is accompanied by Nur77-dependent induction of the cyclin-dependent kinase inhibitor p21.

S Chintharlapalli et al. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J Biol Chem. 2005 Jul 1;280(26):24903-14.

SO Lee et al. p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells. Mol Cancer Res. 2009 Jul;7(7):1169-78.

Nur77 agonist

Chemical name

3,3'-((4-Methoxyphenyl)methylene)bis(1H-indole)

Parent CAS No.

[33985-68-1]

产品资料