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产品名称 AR 244555
产品货号 Axon 2191 CAS [858350-62-6] MF C23H23ClF2N2OMW 416.89 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Inverse agonist of Mas G-protein signaling (IC50 values 186 and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively). AR 244555 caused a dose-dependent inhibition of inositol 1,4,5-trisphosphate accumulation in AdMas-infected cells, and attenuated the sarcomeric organization and cell enlargement observed in Mas overexpressing myocytes.AR 244555 caused a modest but significant increase in coronary flow in rat hearts witout causing arrhythmias, and provides protection from ischemia-reperfusion injury if administered either before ischemia or immediately before reperfusion. References Certificates Categories Extra info T. Zhang et al. Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am. J. Physiol. Heart Circ. Physiol. 2012, 302, H299-311.  Certificate of Analysis Material Safety Data Sheet Angiogenesis Cardiovascular Cell Signaling & Oncology Mas A8 Inverse agonist of Mas G-protein signaling Chemical name (1'-(but-3-enyl)-5-chlorospiro[indoline-3,4'-piperidine]-1-yl)(2,6-difluorophenyl)methanone Parent CAS No. [858350-62-6] Order Size Unit Price Stock 5 mg €125.00 In Stock
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AR 244555

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2191

CAS [858350-62-6]

MF C23H23ClF2N2O
MW 416.89

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

AR 244555

Description

Inverse agonist of Mas G-protein signaling (IC50 values 186 and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively). AR 244555 caused a dose-dependent inhibition of inositol 1,4,5-trisphosphate accumulation in AdMas-infected cells, and attenuated the sarcomeric organization and cell enlargement observed in Mas overexpressing myocytes.AR 244555 caused a modest but significant increase in coronary flow in rat hearts witout causing arrhythmias, and provides protection from ischemia-reperfusion injury if administered either before ischemia or immediately before reperfusion.
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