产品名称

ML314

产品货号

Axon 2632 CAS [1448895-09-7] MF C24H28N4O3MW 420.50 Purity: 100% Soluble in 0.1N HCl(aq) and DMSO Description Brain penetrant nonpeptidic β-Arrestin biased full agonist of the neurotensin NTR1 receptor (EC50 values 2.0 μM and >80 µM for NTR1 and NTR2, respectively). Unlike peptide-based NTR1 agonists, ML314 has no significant response in a Ca2+ mobilization assay. ML314 is a viable, preclinical lead for methamphetamine abuse treatment. KEYWORDS: ML314 | supplier | NTR1 agonist | ML-314 | CAS [1448895-09-7] | Neurotensin | GPCR | drug abuse | allosteric | β-arrestin | dopamine | CNS | BBB

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ML314

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2632

CAS [1448895-09-7]

MF C24H28N4O3
MW 420.50

Purity: 100%
Soluble in 0.1N HCl(aq) and DMSO

ML314

Description

Brain penetrant nonpeptidic β-Arrestin biased full agonist of the neurotensin NTR1 receptor (EC50 values 2.0 μM and >80 µM for NTR1 and NTR2, respectively). Unlike peptide-based NTR1 agonists, ML314 has no significant response in a Ca2+ mobilization assay. ML314 is a viable, preclinical lead for methamphetamine abuse treatment.

LS Barak et al. ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. ACS Chem Biol. 2016 Jul 15;11(7):1880-90.

S Peddibhotla et al. Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. ACS Med Chem Lett. 2013 Jul 20;4(9):846-851.

CNS Pain & Inflammation Endocrinology A7 Neurotensin (NT)

Brain penetrant nonpeptidic β-Arrestin biased agonist of NTR1

Chemical name

2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline

Parent CAS No.

[1448895-09-7]

产品资料