| 产品名称 | EPPTB - RO 5212773 |
| 产品货号 | Axon 2419 CAS [1110781-88-8] MF C20H21F3N2O2MW 378.39 Purity: 100% Soluble in DMSO Description The first, highly potent and selective full antagonist of the trace amine-associated receptor 1 (TAAR1; IC50 value 28 nM at mouse TAAR1). EPPTB blocks the TAAR1-mediated activation of an inwardly rectifying K+ channels. A useful pharmacological tool for in vitro and in vivo investigations to study the role of TAAR1 in psychiatric and neurodegenerative disorders. References Certificates Categories Extra info H. Stalder et al. Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773). Bioorg Med Chem Lett. 2011 Feb 15;21(4):1227-31. A. Bradaia et al. The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20081-6. Certificate of Analysis Material Safety Data Sheet CNS A17 TAAR1 The first, highly potent and selective full antagonist of TAAR1 Chemical name N-(3-ethoxyphenyl)-4-(pyrrolidin-1-yl)-3-(trifluoromethyl)benzamide Parent CAS No. [1110781-88-8] Order Size Unit Price Stock 10 mg €105.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
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EPPTB - RO 5212773Axon 2419 CAS [1110781-88-8] MF C20H21F3N2O2
DescriptionThe first, highly potent and selective full antagonist of the trace amine-associated receptor 1 (TAAR1; IC50 value 28 nM at mouse TAAR1). EPPTB blocks the TAAR1-mediated activation of an inwardly rectifying K+ channels.
The first, highly potent and selective full antagonist of TAAR1
Chemical nameN-(3-ethoxyphenyl)-4-(pyrrolidin-1-yl)-3-(trifluoromethyl)benzamide Parent CAS No.[1110781-88-8] |
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