产品名称

K+ Channel inhibitor 1734

产品货号

Axon 1734 CAS [343240-54-0] MF #N/AMW #N/A Purity: 97% Optical purity: racemate Soluble in DMSO and Ethanol Description Building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1.5 (IKur). The ethylester analog of inhibitor 1734 is a modest inhibitor itself (IC50 value 1.1 µM for human Kv1.5), but exhibiting encouraging KV1.5 versus L-type calcium channel selectivity. KEYWORDS: K+ Channel inhibitor 1734 | supplier | Building block | CAS [343240-54-0] | [1026960-80-4] | Potassium | Kv1.5 | Ikur | BMS | L-type | calcium channel

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

K+ Channel inhibitor 1734

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1734

CAS [343240-54-0]

MF #N/A
MW #N/A

Purity: 97%
Optical purity: racemate
Soluble in DMSO and Ethanol

K+ Channel inhibitor 1734

Description

Building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1.5 (IKur). The ethylester analog of inhibitor 1734 is a modest inhibitor itself (IC50 value 1.1 µM for human Kv1.5), but exhibiting encouraging KV1.5 versus L-type calcium channel selectivity.

HJ Finlay et al. Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1743-7.

KS Atwal et al. Preparation of pyrazolo[1,5-a]pyrimidines as potassium channel inhibitors. PCT Int. Appl. (2001), WO 2001040231 A1 20010607

CNS Pain & Inflammation Non Selective

Building Block for synthesis of Kv1.5 (IKur) inhibitors

Chemical name

methyl 7-(2,3-dichlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

Parent CAS No.

[343240-54-0]

产品资料