PRODUCT NUMBER:

MW: 725,000
Extinction Coefficient: 0.81

Ref: Barrett, A.J. 1979. Biochemistry. 181, 401.

Lyophilized from 30 mM Na Phosphate, pH 7.0 , and 1 mg glycine per 1 mg Alpha 2 Macroglobulin.

Storage: -20°C

Purified Native Human Alpha 2 Macroglobulin, Human Plasma
Bulk Qty Available.

A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.

Purity: >=95% by SDS-PAGE

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Product Citation:
Zhu, Lei, Sari Jäämaa, Taija M. af Hällström, Marikki Laiho, Anna Sankila, Stig Nordling, Ulf‐Håkan Stenman, and Hannu Koistinen. "PSA forms complexes with α1‐antichymotrypsin in prostate." The Prostate 73, no. 2 (2013): 219-226.

Ksiazek M, et al.
Miropin, a Novel Bacterial Serpin from the Periodontopathogen Tannerella forsythia, Inhibits a Broad Range of Proteases by Using Different Peptide Bonds within the Reactive Center Loop.
J Biol Chem. 2015 Jan 2;290(1):658-70. doi: 10.1074/jbc.M114.601716. Epub 2014 Nov 11.