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Synonym: β-Lipoprotein, LDL, Low density lipoprotein

MW: 2,300,000

Liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA
Density: 1.02 to 1.063 g/ml; Composition: 78-80% lipid, 22-20% protein

Storage: 2-6 Degrees C; Do NOT Freeze; Store Away from Light

Shelf Life: at least 3 months remaining

In a normal fasting individual, low density lipoprotein concentrations range from 2.0 - 3.5 g/L. LDL constitutes 50% of the total lipoprotein mass in plasma and is the major carrier of cholesterol and cholesteryl esters. LDL levels strongly correlate with coronary heart disease.

Purity: single arc by IEP against antisera to whole human serum. Essentially free of other plasma lipoproteins and chylomicrons as determined by electrophoresis using a SPIFE Vis Cholesterol gel kit for lipids and Coomassie Blue for proteins. >=95% of total lipoprotein content by electrophoresis.

Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.

Product Citations:
Florian, Maria, Jin Yan, Saad Ulhaq, Melanie Coughlan, Mahemuti Laziyan, William Willmore, and Xiaolei Jin. "Northern Contaminant Mixtures Induced Morphological and Functional Changes in Human Coronary Artery Endothelial Cells under Culture Conditions Typifying High Fat/Sugar Diet and Ethanol Exposure." Toxicology (2013).

Albecka, Anna, Sandrine Belouzard, Anne Op de Beeck, Véronique Descamps, Lucie Goueslain, Justine Bertrand‐Michel, François Tercé, Gilles Duverlie, Yves Rouillé, and Jean Dubuisson. "Role of low‐density lipoprotein receptor in the hepatitis C virus life cycle." Hepatology 55, no. 4 (2012): 998-1007.

Yang X, et al. Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake. J Biol Chem. 2015 Sep 4;290(36):21788-99. doi: 10.1074/jbc.M115.654582. Epub 2015 Jul 17.

McDermott DH Chromothriptic Cure of WHIM Syndrome. (Document S2. Article plus Supplemental Information). Cell. 2015 Feb 12;160(4):686-99. doi: 10.1016/j.cell.2015.01.014. Epub 2015 Feb 5.

Matthew J, et al. Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. Biomaterials. 2014 Oct;35(30):8566-75. doi: 10.1016/j.biomaterials.2014.06.037. Epub 2014 Jul 4.