产品名称 Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody
产品货号 Catalogue No: abx033955
产品价格 现货询价,电话:010-67529703
产品规格 Available Options * Size: 80 µl 400 µl
产品品牌 abbexa
产品概述
产品详情
PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Target PPM1D
Reactivity Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Immunogen KLH-conjugated synthetic peptide between 571-602 amino acids from the C-terminal region of human PPM1D.
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Swiss Prot O15297
Gene Symbol PPM1D
NCBI Accession NP_003611.1
Buffer PBS containing 0.09% sodium azide.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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