Transforming Growth Factor beta 2 (TGF-beta 2) is a member of the TGF superfamily, and exists alongside 2 other mammalian isoforms of TGF-beta – TGF-beta 1 and TGF-beta 3 – which share a pair of receptors. All three isoforms are secreted by most cell types, and for regulatory control, must be activated before they exert functional activity. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. TGF-beta2 can induce differentiation, apoptosis, and angiogenesis.