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| Product Name | b-Catenin/Tcf Inhibitor V, BC21 |
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| Description | Purity ≥95% (HPLC). A cell-permeable dimeric copper complex that competitively binds b-catenin and disrupts b-catenin/Tcf4 interaction reversibly (IC50=5.0uM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in b-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤10uM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50uM). Synonyms: Copper, di-u-chlorobis[1-[(1-piperidinyl-kN)methyl]-2-naphthalenolato-kO]di-(9Cl), Wnt Pathway Inhibitor XV CAS No: 691005-38-6 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | b-Catenin/Tcf Inhibitor V, BC21 (Copper, di-u-chlorobis[1-[(1-piperidinyl-kN)methyl]-2-naphthalenolato-kO]di-(9Cl), Wnt Pathway Inhibitor XV) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217208 |
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| Order / More Info | b-Catenin/Tcf Inhibitor V, BC21 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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