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| Product Name | TRAF6, Recombinant, Human, aa1-522, His-SUMO-Tag (TNF Receptor-associated Factor 6) |
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| Description | Purity ~90% (SDS-PAGE). E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. Source: Recombinant prote |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | E3 ubiquitin-protein ligase TRAF6, Interleukin-1 signal transducer, RING finger protein 85 |
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| Gene, Accession, CAS # | SwissProt: Q9Y4K3 |
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| Catalog # | 375664 |
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| Order / More Info | TRAF6, Recombinant, Human, aa1-522, His-SUMO-Tag (TNF Receptor-associated Factor 6) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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