| 产品详情 |
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| Product Name | IPBT-5CA |
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| Description | Purity >97%. The G protein-coupled receptors GPR109A and GPR109B are recognized to be receptors for hydroxy-carboxylic acid (HCA) metabolites, are abundant in adipocytes, and are relevant to atherosclerosis and dyslipidemia. IPBT-5CA is a selective agonist of GPR109B (HCA3; EC50 = 400 nM). It displays no activity at GPR109A (HCA2). IBC-293 inhibits forskolin-stimulated cAMP release in Chinese hamster ovary cells stably expressing GPR109B (EC50 = 54 nM) but not in cells expressing GPR109A. This is accompanied by a rapid and transient increase in intracellular calcium and activation of ERK1/2 through a pertussis toxin-sensitive Gi signaling pathway. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(1-methylethyl)-1H-benzotriazole-5-carboxylic acid, IBC-293 |
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| Gene, Accession, CAS # | CAS: 306935-41-1 |
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| Catalog # | LS-H115 |
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| Order / More Info | IPBT-5CA from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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