| 产品详情 |
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| Product Name | Recombinant Bordetella pertussis Pertussis toxin subunit 1 |
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| Description | 35-269aa; Full Length. MW: 30.3kD. Purity >90% as determined by SDS-PAGE. S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B. pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD+ into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding prote |
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| Size | 0.01 mg (E-Coli), 0.01 mg (Yeast), 0.05 mg (E-Coli), 0.05 mg (Yeast), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Islet-activating protein S1; IAP S1; NAD-dependent ADP-ribosyltransferase (EC:2.4.2.-)] |
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| Gene, Accession, CAS # | ptxA, Gene ID: 2665068, Accession: NP_882282.1 |
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| Catalog # | MBS1095030 |
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| Order / More Info | Recombinant Bordetella pertussis Pertussis toxin subunit 1 from MYBIOSOURCE INC. |
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| Product Specific References | Cloning and sequencing of the pertussis toxin genesoperon structure and gene duplication.Nicosia A., Perugini M., Franzini C., Casagli M.C., Borri M.G., Antoni G., Almoni M., Neri P., Ratti G., Rappuoli R.Proc. Natl. Acad. Sci. U.S.A. 83:4631-4635(1986) Pertussis toxin genenucleotide sequence and genetic organization.Locht C., Keith J.M.Science 232:1258-1264(1986) A unique sequence of the Bordetella pertussis toxin operon.Loosmore S.M., Cunningham J.D., Bradley W.R., Yao E.L., Dekaban G.A., Klei |
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