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| Product Name | p70 S6 Kinase (T412E), active, Recombinant, Human, His-Tag, aa1-421 (p70 S6K) |
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| Description | Purity ~90%. Purified by Ni-NTA agarose, activated with PDK1 and re-purified using Heparin Sepharose Chromatography. Purity is verified by SDS-PAGE. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. Source: A truncated, N-terminus His-tagged fusion protein corresponding to aa1-421 of human p70 S6 Kinase (containing a T412E mutation and a D18H mutation) expressed in Sf21 cells. The T412E mutant is more efficiently activated by |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P23443 |
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| Catalog # | P1001-37B |
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| Order / More Info | p70 S6 Kinase (T412E), active, Recombinant, Human, His-Tag, aa1-421 (p70 S6K) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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