| 产品详情 |
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| Product Name | 1,4-DPCA |
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| Description | Purity >98%. The pro-angiogenic factor HIF-1Alpha is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-Alpha prolyl hydroxylase (HIF-PH). Inhibitors of prolyl 4-hydroxylase are potentially useful in controlling excess collagen deposition in pathological fibrosis. 1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase in embryonic chick tendon cells and of collagen hydroxylation in human foreskin fibroblasts with an IC50 value of 3.6 and 2.4 µM, respectively. Beta-oxocarboxylic acids such as 1,4-DPCA have also been found to inhibit the asparaginyl-hydroxylase, factor inhibiting HIF (FIH), with an IC50 value of 60 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4,4a-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid, 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid |
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| Gene, Accession, CAS # | CAS: 331830-20-7 |
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| Catalog # | LS-H5750 |
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| Price | |
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| Order / More Info | 1,4-DPCA from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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