| 产品详情 |
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| Product Name | 2,4-DPD |
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| Description | Purity >98%. The pro-angiogenic factor HIF-1Alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-Alpha prolyl hydroxylase (HIF-PH). 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor Alpha-keto glutarate, with effective concentrations in the low µM range. 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1Alpha system. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,4-pyridinedicarboxylic acid, diethyl ester, 2,4-Diethylpyridine dicarboxylate |
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| Gene, Accession, CAS # | CAS: 41438-38-4 |
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| Catalog # | LS-H5938 |
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| Order / More Info | 2,4-DPD from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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