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| Product Name | K-Ras Activation Assay |
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| Description | Background: Small GTP-binding proteins (or GTPases) are a family of proteins that serve as molecular regulators in signaling transduction pathways. Ras, a 21 kDa protein, regulates a variety of biological response pathways that include cell growth, cell transformation and tumor invasion. Like other small GTPases, Ras regulates molecular events by cycling between an inactive GDP-bound form and an active GTP-bound form. In its active (GTP-bound) state, Ras binds specifically to the Ras-binding dom |
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| Size | 5 assays, 20 assays, |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS168791 |
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| Order / More Info | K-Ras Activation Assay from MYBIOSOURCE INC. |
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| Product Specific References | 1. Bar-Sagi D., and Hall A. (2000) Cell 103: 227-38.2. de Rooij J., and Bos J. L. (1997) Oncogene 14: 623-5.1. Hernandez-Porras, I. et al. (2014). K-RasV14I Recapitulates Noonan Syndrome in Mice. Proc Natl Acad Sci U S A. 111:16395-16400. 2. Moran, D. M. et al. (2014). KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non-Small Cell Lung Cancer Cells. Mol Cancer Ther. 13:1611-1624. |
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