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| Product Name | K-Ras(G12C) Inhibitor 9 |
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| Description | Purity >98%. K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 µM for 24 hours in vitro . K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide |
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| Gene, Accession, CAS # | CAS: 1469337-91-4 |
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| Catalog # | LS-H8364 |
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| Order / More Info | K-Ras(G12C) Inhibitor 9 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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