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| Product Name | K-Ras(G12C) Inhibitor 12 |
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| Description | Purity >95%. K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-2-propen-1-one |
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| Gene, Accession, CAS # | CAS: 1469337-95-8 |
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| Catalog # | LS-H8363 |
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| Price | |
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| Order / More Info | K-Ras(G12C) Inhibitor 12 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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