| 产品详情 |
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| Antigenic Specificity | ATG14 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | Protein G purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, IF, IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ATG14 Antibody LS-C501091. Specificity: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity). |
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| Immunogen | Recombinant Human Beclin 1-associated autophagy-related key regulator protein (1-492AA) |
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| Other Names | ATG14, Autophagy related 14, Beclin 1-Interacting protein, KIAA0831, ATG14L, BARKOR |
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| Gene, Accession # | ATG14, Gene ID: 22863 |
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| Catalog # | LS-C501091 |
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| Price | |
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| Order / More Info | ATG14 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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