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| Product Name | PLA2R1, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE). PLA2R1 also called muscle (M-)type PLA2R or secretory (s)PLA2R is a 180-200kD type I transmembrane glycoprotein that is a member of subgroup VI of the C-type lectin superfamily. The 1487aa mouse PLA2R1 contains a 26aa signal sequence, a 1370 aa ECD, a 21aa transmembrane sequence, and a 70aa cytoplasmic domain with an endocytosis motif. The ECD contains one ricin B-type lectin domain aa42-165, a fibronectin type II region aa176-224, and eight C-type lectin carbohydrate recognition domains CRDs, aa241-1377. CRDs 3-5 are the major PLA2 binding site. The mouse PLA2R1 ECD shares 75% and 86% aa identity with human and rat PLA2R1, respectively. One isoform shows a 35aa N-terminal extension, and a potentially secreted isoform contains a 10aa substitution for aa680-1487. Matrix metalloproteinases can generate a 180kD soluble inhibitory form in mouse serum that retains PLA2 binding activity. Mouse PLA2R1 is widely expressed, including on type II alveolar cells, neutrophil |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PLA2R1, Recombinant, Mouse (Secretory Phospholipase A2 Receptor, PLA2-R, PLA2R, 180kD Secretory Phospholipase A2 Receptor, M-type Receptor, Pla2g1br) |
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| Gene, Accession, CAS # | Accession: NP_032893 |
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| Catalog # | P4074-11R |
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| Order / More Info | PLA2R1, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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