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| Product Name | PELI2, Recombinant, Human, aa1-420, His-Tag (E3 Ubiquitin-Protein Ligase Pellino Homolog 2) |
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| Description | Purity ~80% (SDS-PAGE). PELI2 is an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. This protein is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 may be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. It can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Source: Recombinant protein corresponding to aa1-420 from human PELI2, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~48.8kD (443aa), confirmed by MALDI-TOF Applications: Suitable for use in SDS-PAGE. |
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| Size | 50ug, 250ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_067078 |
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| Catalog # | 218441 |
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| Order / More Info | PELI2, Recombinant, Human, aa1-420, His-Tag (E3 Ubiquitin-Protein Ligase Pellino Homolog 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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