| 产品详情 |
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| Product Name | SRPK Inhibitor, SRPIN340 |
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| Description | Purity ~99% (HPLC). A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Formula: C18H18F3N3O Solubility: DMSO Molar Mass: 349.4 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SRPK Inhibitor, SRPIN340 (N-(2-Piperidin-1-yl-5-(trifluoromethyl)phenyl)isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217809 |
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| Order / More Info | SRPK Inhibitor, SRPIN340 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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