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| Product Name | MAPKAP1, Recombinant, Human, aa2-522, His-SUMO-Tag (Target of Rapamycin Complex 2 Subunit MAPKAP1) |
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| Description | Purity ~90% (SDS-PAGE). Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphoryl |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mitogen-activated protein kinase 2-associated protein 1, Stress-activated map kinase-interacting protein 1, SAPK-interacting protein 1, mSIN1 |
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| Gene, Accession, CAS # | SwissProt: Q9BPZ7 |
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| Catalog # | 374150 |
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| Order / More Info | MAPKAP1, Recombinant, Human, aa2-522, His-SUMO-Tag (Target of Rapamycin Complex 2 Subunit MAPKAP1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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