| 产品详情 |
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| Product Name | AZD 2932 |
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| Description | Purity >98%. AZD 2932 is an inhibitor of VEGFR2, PDGFRBeta, CSF1R, c-KIT, and FLT3 receptor tyrosine kinases (IC50 s = 4, 8, 100, 9, and 7 nM, respectively). It also inhibits PdgfrAlpha phosphorylation (IC50 = 2 nM) in lysates from C6 rat glial tumors grown in athymic mice. AZD 2932 (12.5-50 mg/kg) reduces tumor growth and inhibits PdgfrBeta and Vegfr2 phosphorylation in a 1:1 ratio in a C6 mouse xenograft model. Xenograft models using non-PDGFR expressing tumor cells were insensitive to AZD 2932 treatment. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-benzeneacetamide |
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| Gene, Accession, CAS # | CAS: 883986-34-3 |
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| Catalog # | LS-H6699 |
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| Order / More Info | AZD 2932 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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