| 产品详情 |
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| Product Name | AZD 5363 |
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| Description | Purity >98%. Akt functions as a key component in multiple signaling pathways including those related to cell proliferation, metabolism, and survival as well as angiogenesis. AZD 5363 is a pyrrolopyrimidine-derived compound that inhibits Akt by competitively binding to the kinase domain, preventing substrate phosphorylation by Akt. It inhibits Akt1, 2, and 3 with IC50 values of 3, 7, and 7 nM, respectively and also inhibits P70S6K and PKA with similar potency (IC50 s = 6 and 7 nM, respectively). Furthermore, AZD 5363 shows >75% inhibition at 1 µM against ROCK-II, MKK1, MSK1, MSK2, PKCGamma, PKGAlpha, PKGBeta, PRKX, RSK2, and RSK3. At 3 µM or less, AZD 5363 has been reported to inhibit the proliferation of 41 out of 182 solid and hematologic tumor cell lines, demonstrating the greatest sensitivity towards breast cancer derived-cells or those with PIK3CA and/or PTEN mutations. Oral dosing to nude mice bearing BT474c xenografts resulted in antitumor activity, including the reduction of the phosphorylation of PRAS40, GSK3Beta, and S6 at an EC50 value of ~ 0.1 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide |
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| Gene, Accession, CAS # | CAS: 1143532-39-1 |
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| Catalog # | LS-H6706 |
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| Order / More Info | AZD 5363 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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