| 产品详情 |
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| Product Name | Akt Inhibitor VIII |
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| Description | Purity >98%. Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBAlpha, Beta, Gamma) modulate cell proliferation, metabolism, and survival as well as angiogenesis. Akt inhibitor VIII is a potent allosteric inhibitor of Akt1 and Akt2 (IC50 s = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC50 = 2.2 µM). It is a poor or ineffective inhibitor of a wide range of other serine-threonine kinases. Akt inhibitor VIII is cell permeable, blocking insulin regulation of forkhead box 01 activity at 1 µM in rat hepatoma cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one |
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| Gene, Accession, CAS # | CAS: 612847-09-3 |
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| Catalog # | LS-H6456 |
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| Order / More Info | Akt Inhibitor VIII from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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