| 产品详情 |
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| Product Name | Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 |
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| Description | Purity ≥95% by HPLC. A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. |
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| Size | 1mg, 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2) |
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| Gene, Accession, CAS # | CAS: 612847-09-3 |
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| Catalog # | 29414 |
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| Price | |
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| Order / More Info | Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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