| 产品详情 |
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| Product Name | Akt Inhibitor X |
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| Description | Purity >95%. Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 µM. This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 µM. Inhibition of Akt phosphorylation by 5 µM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-chloro-N,N-diethyl-10H-phenoxazine-10-butanamine, monohydrochloride, 10-DEBC |
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| Gene, Accession, CAS # | CAS: 925681-41-0 |
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| Catalog # | LS-H6457 |
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| Order / More Info | Akt Inhibitor X from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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