| 产品详情 |
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| Product Name | Akt Inhibitor XVI, AT7867 |
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| Description | Purity ~99% (HPLC). A cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt (IC50 = 32, 17, and 47nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50 = 20nM), and p70S6K (IC50 = 85nM) in an ATP-competitive manner (Ki = 18nM using AKT2), with much reduced potency toward RSK1 (IC50 >100nM) and a panel of 13 other cellular kinases (IC50 >1uM). Shown to reduce cellular phosphorylation of GSK-3beta (IC50 range from 2.08 to 4.45uM), S6R, FKHRL1, and inhibit the proliferation of cancer cells exhibiting constitutive Akt pathway activation both in vitro (IC50 range from 0.94 to 11.86uM) and in mice in vivo (20mg/kg via i.p. or 90mg/kg via p.o.). Formula: C20H20ClN3 Solubility: DMSO Molar Mass: 337.9 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Akt Inhibitor XVI, AT7867 (p70S6K Inhibitor III, 4-(4-Chlorophenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine, PKA Inhibitor XIV, Chlorophenyl-pyrazolyl-phenyl-piperidine, S6K1 Inhibitor III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217171 |
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| Order / More Info | Akt Inhibitor XVI, AT7867 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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