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| Product Name | Combrestatin A4 3'-O-Phosphate (sodium salt) |
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| Description | Purity >97%. Combretastatin A4 (CA4) is a potent inhibitor of tubulin polymerization that displays strong inhibitory activity on tumor cell growth. Combretastatin-A-4-3'-O-Phosphate (CA4P) is a CA4 prodrug that inhibits tumor growth in several cell lines including P-388 (leukemia), SK-N-SH (neuroblast), BXPC-3 (pancreas), NCI-H460 (lung), and DU-145 (prostate) with ED50 values of 0.0029, 0.00025, 0.23, 0.00035, and 0.00072 ug/ml, respectively. CA4P specifically targets the tumor vasculature. In a rat model of carcinosarcoma, CA4P delivered intraperitoneally at a dose of 100 mg/kg effectively disrupts tumor blood flow within six hours after administration without significantly affecting normal tissues. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol, dihydrogen phosphate, disodium salt, CA4P, CombrestatinA4, CRC87-09 |
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| Gene, Accession, CAS # | CAS: 168555-66-6 |
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| Catalog # | LS-H12 |
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| Order / More Info | Combrestatin A4 3'-O-Phosphate (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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