| 产品详情 |
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| Product Name | Combretastatin A1 |
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| Description | Purity >98%. Combretastatin A1 is a cis -stilbene originally isolated from C. caffrum that inhibits microtubule assembly (ID50 = 2 µM) by binding to the colchicine binding site on Beta-tubulin. It inhibits proliferation of hepatocellular carcinoma (IC50 s = 9.2-728.2 nM) and other carcinoma cell lines (IC50 s = 12.2-2,247 nM). Combretastatin A1 increases apoptosis of HepG2 cells in a GSK3Beta-dependent manner by decreasing the levels of MCL-1 and Beta-catenin. It inhibits tumor growth in a hepatocellular carcinoma mouse xenograft model when administered at doses of 2 or 4 mg/kg for 4 weeks. It also enhances the effects of carboplatin , paclitaxel , and cisplatin in murine models of cancer. Combretastatin A1 decreases functional vascular volume within hours in a well-vascularized murine colon adenocarcinoma model. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-methoxy-6-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-1,2-benzenediol, CA1 |
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| Gene, Accession, CAS # | CAS: 109971-63-3 |
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| Catalog # | LS-H7225 |
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| Price | |
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| Order / More Info | Combretastatin A1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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