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| Product Name | Combretastatin A4 |
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| Description | Purity >98% by HPLC. A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, it disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and thus the activity of the VE-cadherin/Beta-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho-xyphenyl)ethenyl]phenol, NSC 817373, CRC 87-09 |
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| Gene, Accession, CAS # | CAS: 117048-59-6 |
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| Catalog # | LS-H2824 |
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| Order / More Info | Combretastatin A4 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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