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| Product Name | Active Recombinant Human FLt3 ligand |
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| Description | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. FLt3 ligand is a transmembrane glycoprotein that activates the FLt3 receptor (CD135, FLK2). FLT3 ligand, in synergy with other cytokines, stimulates the growth and differentiation of a number of important cell populations. Activation of FLt3 stimulates the growth and differentiation of very early stem cells involved in haematopoiesis, myelopoiesis, erythropoiesis and megakaryopoiesis. FLt3 activation mobilizes hematopoietic progenitor cells into peripheral blood and induces proliferation of myeloid and dendritic cells (DC). Dysregulation of FLt3 has been associated with acute leukaemia(s) involving myeloid (AML), T, and B blast cell(s). Recombinant human FLt3 is a polypeptide chain containing 165 amino acids (27-181 of P49771-1 FLT3L_HUMAN). It has a predicted molecular mass of 18.4 kDa, however as result of potential glycosylation, the recombinant protein could migrate with an apparent molecular mass of 18-25 kDa in SDS-PAGE. Purity >97% by SDS-PAGE gel |
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| Size | 1 µg, 5 µg, 10 ug, 50ug, 500ug |
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| Concentration | n/a |
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| Applications | Functional studies, Cell culture, Western Blot. |
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| Other Names | SL cytokine |
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| Gene, Accession, CAS # | UniProt: P49771 |
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| Catalog # | RF0039/40/41 |
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| Order / More Info | Active Recombinant Human FLt3 ligand from AGRENVEC |
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| Product Specific References | - Nin, D.S. et al., 2012. Role of Misfolded N-CoR Mediated Transcriptional Deregulation of Flt3 in Acute Monocytic Leukaemia (AML)-M5 Subtype. PLoS One 7(4):e34501. - Moore, M.A. et al., 2007. Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells. Exp. Hematol., 35: 105-116. - Parcells, B.W. et al., 2006. FMS-like tyrosine kinase 3 in normal haematopoiesis and acute myeloid leukaemia. Stem Cells, 24:1174-1184. - Muench, M.O. et al., 1995. FLK-2/FLt-3 ligand regulates the growth of early myeloid progenitors isolated from human foetal liver. Blood, 85: 963-972. - Agne`s, F. et al., 1994. Genomic structure of the downstream part of the human FLt3 gene: exon/intron structure conservation among genes encoding receptor tyrosine -kinases (RTK) of subclass III. Gene, 145: 283-288. |
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