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| Product Name | Active Recombinant Human VEGF 165a |
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| Description | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. Vascular endothelial growth factor is a member of the platelet-derived growth factor family. It is a specific mitogen for vascular endothelial cells in vitro and a strong angiogenic factor in vivo. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo and is also a chemo attractant for monocytes cells. VEGF binds to the FLT1/VEGFR1 and KDR/VEGFR2 present on endothelial cells. Substantial evidence implicates VEGF in the induction of tumour metastasis by stimulating the production of matrix metalloproteinase (MMPs). Recombinant full length VEGF is a 38.2 kDa homodimeric protein consisting of two 165 amino acid polypeptide chains (amino acids 27-191 P15692-4 VEGFA_HUMA) with His tag at N-terminal. Purity >97% by SDS-PAGE gel |
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| Size | 1 µg, 10 µg, 100 µg, 250 µg |
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| Concentration | n/a |
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| Applications | Functional studies, Cell assay, SDS-PAGE, Western Blot, Antibody Production. |
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| Other Names | VEGF-A, Vascular permeability factor, VPF |
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| Gene, Accession, CAS # | UniProt: P15692 |
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| Catalog # | RF0104 |
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| Order / More Info | Active Recombinant Human VEGF 165a from AGRENVEC |
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| Product Specific References | - Ferrara, N., 1999. Molecular and Biological properties of vascular endothelial growth factor. J. Mol. Med., 77 () 527-543. - Detmar, M., 2000. The role of VEGF and thrombospondins in skin Angiogenesis. Journal of Dermatological Science, 24 Suppl. 1 S78-S84. - Ferrara, N., 2001. Role of vascular endothelial growth factor in regulation of Physiological angiogenesis. Am. J.Physiol. Cell Physiol., 280 C1358-C1366. - Bao, P. et al., 2009. The role of vascular endothelial growth factor in wound healing. J Surg Res., 153(2):347-58. |
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